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- Title
Serum β<sub>2</sub>-Microglobulin in Patients with Adult T-Cell Leukemia.
- Authors
Tsuda, Hiroyuki; Ishii, Toshinori; Sawada, Tomohiro; Takatsuki, Kiyoshi
- Abstract
Thirty-seven patients with adult T-cell leukemia had serum β2-microglobulin (β2M) estimated at presentation. A significant association was found between β2M and the subtypes of the disease: β2M in the acute type is significantly higher than in the chronic and smoldering types (p < 0.01), and β2M in the lymphoma type is apparently higher than in the chronic and smoldering types, although the difference between the lymphoma and chronic types was not statistically significant. An apparent reduction in β2M levels after chemotherapy was observed in 7 patients who reached partial or complete remission. One patient who was resistant to chemotherapy showed elevated β2M values even after intensive chemotherapy. In another patient, who attained partial remission with a concordant reduction in β2M, renewed elevation of β2M was observed in parallel with exacerbation of other parameters such as lactate dehydrogenase (LDH), WBC, calcium and clinical manifestations. Correlation analysis was carried out between β2M, LDH, calcium, lymphoid cell count and the grade of clinical severity. The β2M level was moderately correlated with LDH, calcium, the grade of clinical severity but not with the lymphoid cell count. The clinical severity also correlated with LDH and calcium but to a lesser extent than with β2M. These data support the use of the β2M in the evaluation of adult T-cell leukemia. Copyright © 1991 S. Karger AG, Basel
- Publication
Acta Haematologica, 1991, Vol 86, Issue 1, p31
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000204795