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- Title
Characterization of a non-functional erm(T) gene in a clinical Enterococcus faecium strain.
- Authors
Cinthi, Marzia; Coccitto, Sonia Nina; Simoni, Serena; Zeni, Guido; Mazzariol, Annarita; Pocognoli, Antonella; Du, Xiang-Dang; Brenciani, Andrea; Giovanetti, Eleonora
- Abstract
This article, published in the Journal of Antimicrobial Chemotherapy, discusses the characterization of a non-functional erm(T) gene in a clinical strain of Enterococcus faecium. The erm(T) gene is typically associated with inducible erythromycin resistance in lactobacilli, streptococci, and staphylococci. However, this study identified an erythromycin-susceptible E. faecium strain that harbored a defective erm(T) gene. Whole-genome sequencing revealed that the strain belonged to clonal complex CC17 and that the erm(T) gene was located on a chromosomal integrative and conjugative element. This is the first report of a non-functional erm(T) gene with rearrangements in the leader peptide and coding sequence, potentially explaining the strain's erythromycin susceptibility. The study was supported by a grant from MIUR-Italy.
- Subjects
ENTEROCOCCUS faecium; GENE rearrangement; AMINO acid sequence; NUCLEOTIDE sequencing; GENES; ENTEROCOCCUS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2023, Vol 78, Issue 12, p3006
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkad321