We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Moving forward with reactive oxygen species involvement in antimicrobial lethality.
- Authors
Zhao, Xilin; Hong, Yuzhi; Drlica, Karl
- Abstract
Support for the contribution of reactive oxygen species (ROS) to antimicrobial lethality has been refined and strengthened. Killing by diverse antimicrobials is enhanced by defects in genes that protect against ROS, inhibited by compounds that block hydroxyl radical accumulation, and is associated with surges in intracellular ROS. Moreover, support has emerged for a genetic pathway that controls the level of ROS. Since some antimicrobials kill in the absence of ROS, ROS must add to, rather than replace, known killing mechanisms. New work has addressed many of the questions concerning the specificity of dyes used to detect intracellular ROS and the specificity of perturbations that influence ROS surges. However, complexities associated with killing under anaerobic conditions remain to be resolved. Distinctions among primary lesion formation, resistance, direct lesion-mediated killing and a self-destructive stress response are discussed to facilitate efforts to potentiate ROS-mediated bacterial killing and improve antimicrobial efficacy.
- Subjects
REACTIVE oxygen species; FREE radicals; IONIZATION of gases; ANTI-infective agents; DRUGS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2015, Vol 70, Issue 3, p639
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dku463