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- Title
Electrochemical‐Induced C(sp<sup>3</sup>)−H Dehydrogenative Trimerization of Pyrazolones to Tripyrazolones.
- Authors
Ma, Jing; Yang, Jianjing; Yan, Kelu; Sun, Xue; Wei, Wei; Tian, Laijin; Wen, Jiangwei
- Abstract
The electrochemical‐induced three‐component C(sp3)−H dehydrogenative trimerization of pyrazolones to tripyrazolones with hydrogen evolution has been accomplished under the metal‐ and external‐oxidant‐free conditions. This protocol provides an efficient and eco‐friendly method for the synthesis of tripyrazolones, which avoids the use of metals and stoichiometric chemical oxidants. A wide range of functional groups was tolerated to give selectively the desired products in high yields. Importantly, such an electrochemical‐oxidation‐induced dehydrogenative trimerization reaction could be easily scaled up with excellent efficiency.
- Subjects
TRIMERIZATION; PYRAZOLONES; FUNCTIONAL groups
- Publication
European Journal of Organic Chemistry, 2021, Vol 2021, Issue 40, p5491
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202100988