We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A Naphthalimide‐Based ND‐O‐EAc Photocatalyst for Sulfonation of Alkenes to Access β‐Ketosulfones Under Visible Light.
- Authors
Yang, Xiaoting; Yang, Jianjing; Yan, Kelu; Qin, Hongyun; Dong, Wenjie; Wen, Jiangwei; Wang, Hua
- Abstract
The development of facile, efficient, cost‐effective, and visible light‐driven photocatalysts for organic synthetic chemistry has received increasing attention. This protocol has initially synthesized a naphthalimide‐based ND‐O‐EAc visible light photocatalyst for the sulfonation of alkenes to produce β‐ketosulfones. Compared with the current photosynthetic strategies, the newly developed catalytic system has some merits, namely high efficiency, gram‐scale preparation of low‐cost photocatalyst, no metal contamination, wide substrate scope, and green terminal oxidant of air. Moreover, the prepared photocatalyst of ND‐O‐EAc is feasible for the sulfonation reactions of androstenones. Importantly, such a photocatalysis strategy can easily realize the scale‐up synthesis for β‐ketosulfone drugs under the mild conditions up to 90 % yield.
- Subjects
VISIBLE spectra; SULFONATION; ORGANIC chemistry; ALKENES; DRUG synthesis
- Publication
European Journal of Organic Chemistry, 2020, Vol 2020, Issue 23, p3456
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202000423