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- Title
Selectfluor-Mediated Synthesis of Fluoro Spiro 3(2H)-Furanone Derivatives via Domino Fluorination-Defluorination.
- Authors
Krishna Swaroop, Desireddy; Ravi Kumar, Nagiri; Nagender, Punna; Jitender Dev, Gaddameedi; Jagadeesh Babu, Nanubolu; Narsaiah, Banda
- Abstract
An unprecedented Domino transformation towards diverse fluorinated spiro benzothiazinyl furanone scaffolds has been developed from 1,3-diketone embedded benzothiazines and Selectfluor through fluorinative intramolecular cyclization. The transformation is triggered by fluorine insertion to form a difluoro intermediate, which is responsible for the formation of fluorinated spiro 3(2H)-furanone derivatives. We have also succeeded to synthesize non-fluorinated spiro 3(2H)-furanone derivatives by oxidative cyclization using AgF.
- Subjects
FURANONE synthesis; FLUORINATION; THIAZINES; CHEMICAL derivatives; RING formation (Chemistry)
- Publication
European Journal of Organic Chemistry, 2018, Vol 2018, Issue 3, p413
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201701668