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- Title
Comparison of the outcome of conventional osteosarcoma at two specialist international orthopaedic oncology centres.
- Authors
Ford, Samuel; Saithna, Adnan; Grimer, Robert J.; Picci, Piero
- Abstract
Objective : To determine the prognostic value of patient and treatment parameters in osteosarcoma, and whether these are equally important across international boundaries. Design : Retrospective, cross-sectional study of 428 patients diagnosed with around-knee osteosarcoma, between 1990 and 1997 in Birmingham, UK, and Bologna, Italy. Disease-free survival (DFS) and overall survival (OS) assessed by Kaplan-Meier, Fisher's PLSD and Cox proportional hazard regression. Results : Five-year DFS and OS were 56 and 73% at Centre 1, compared to 43 and 60% at Centre 2 ( P = 0.0022 and P = 0.025, respectively). The most important bad prognostic factors for DFS and OS respectively were raised alkaline phosphatase at diagnosis ( P = 0.002 and P = 0.003), tumour necrosis < 90% following chemotherapy ( P = 0.001 and P = 0.004) and volume >150 cm 3 at diagnosis ( P = 0.04 and P = 0.006). The most significant combination of bad prognostic factors was alkaline phosphatase and tumour necrosis. A total of 73% of patients at Centre 1 had greater than 90% necrosis of the tumour following neoadjuvant chemotherapy compared with 29% at Centre 2. Conclusions : Tumour-based prognostic factors have similar significance across international boundaries. Chemotherapy effectiveness appears to be a major factor in explaining the survival difference between the two centres.
- Subjects
OSTEOSARCOMA; SARCOMA; BONE cancer; ORTHOPEDICS; ONCOLOGY; TUMORS
- Publication
Sarcoma, 2004, Vol 8, Issue 1, p13
- ISSN
1357-714X
- Publication type
Article
- DOI
10.1080/13577140410001679202