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- Title
Immunohistochemical Marker Expression in Temporal Bone Squamous Cell Carcinoma.
- Authors
Daisuke MAKI; Kenji OKAMI; Koji EBISUMOTO; Akihiro SAKAI; Masashi HAMADA; Go OGURA; Tomoaki MURAKAMI; Mayu YAMAUCHI; Kosuke SAITO; Shoji KANEDA; Naoya NAKAMURA
- Abstract
Background: The correlation between genomic mutations (or the overexpression of abnormal proteins) and prognosis in temporal bone squamous cell carcinoma (TBSCC) is not clear. We investigated the overexpression of EGFR and p53 as a pathological biomarker for predicting the clinical course of patients with TBSCC. Methods: We performed a retrospective review of 22 TBSCC cases treated in Tokai University Hospital between January 2005 and October 2016. We assessed the overexpression of EGFR and p53 in TBSCC patients through immunohistochemical staining. We also evaluated the association between the overexpression of these proteins and clinicopathological variables, including survival outcomes. Results: The primary lesion in all patients was the external auditory canal. Nine (40.9%) patients were EGFR positive, and 9 (40.9%) were p53 positive. The 5-year overall survival rate for EGFR-positive patients (55.6%) was significantly lower (p = 0.043) than that of the EGFR-negative patients (92.3%). Conclusion: EGFR overexpression in TBSCC patients may be a prognostic biomarker.
- Subjects
SQUAMOUS cell carcinoma; IMMUNOHISTOCHEMISTRY; TEMPORAL bone tumors; GENETIC mutation; BIOMARKERS; EPIDERMAL growth factor receptors
- Publication
Tokai Journal of Experimental & Clinical Medicine, 2021, Vol 46, Issue 2, p89
- ISSN
0385-0005
- Publication type
Article