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- Title
Relationships between mixed features and borderline personality disorder in 2811 patients with major depressive episode.
- Authors
Perugi, G.; Angst, J.; Azorin, J.‐M.; Bowden, C. L.; Caciagli, A.; Mosolov, S.; Vieta, E.; Young, A. H.
- Abstract
Objective The study focused on the relationship between mixed depression and borderline personality disorder ( BPD). Method The sample comprised 2811 patients with a major depressive episode ( MDE). Clinical characteristics were compared in patients with ( BPD+) and without ( BPD−) comorbid BPD and in BPD+ with ( MXS+) and without ( MXS−) mixed features according to DSM-5 criteria. Results A total of 187 patients (6.7%) met the criteria for BPD. A DSM- IV- TR diagnosis of bipolar disorder ( BD) was significantly more frequent in patients with BPD+ than in patients with BPD. Patients with BPD+ were significantly younger and reported lower age at onset than BPD−. Patients with BPD+ also showed more hypomania/mania in first-degree relatives in comparison with patients with BPD−, as well as more psychiatric comorbidity, mixed features, atypical features, suicide attempts, prior mood episodes and antidepressant-induced hypo/manic switches. Mixed features according to DSM-5 criteria were observed in 52 (27.8%) BPD+. In comparison with MXS−, MXS+ were significantly younger at age of onset and at prior mood episode and had experienced more mood episodes and hypo/manic switches with antidepressant treatments. Conclusion Major depressive episode patients with comorbid BPD reported a high prevalence of mixed features and BD. The presence of DSM-5 mixed features in MDE patients with BPD may be associated with complex course and reduced treatment response.
- Subjects
MENTAL depression; COMORBIDITY; MIXED state (Superconductors); BORDERLINE personality disorder; AFFECTIVE disorders
- Publication
Acta Psychiatrica Scandinavica, 2016, Vol 133, Issue 2, p133
- ISSN
0001-690X
- Publication type
Article
- DOI
10.1111/acps.12457