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- Title
The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk.
- Authors
Zhu, Xueyi; Cui, Jie; Yi, La; Qin, Jingjing; Tulake, Wuniqiemu; Teng, Fangzhou; Tang, Weifeng; Wei, Ying; Dong, Jingcheng
- Abstract
Asthma is associated with innate and adaptive immunity mediated by immune cells. T cell or macrophage dysfunction plays a particularly significant role in asthma pathogenesis. Furthermore, crosstalk between them continuously transmits proinflammatory or anti-inflammatory signals, causing the immune cell activation or repression in the immune response. Consequently, the imbalanced immune microenvironment is the major cause of the exacerbation of asthma. Here, we discuss the role of T cells, macrophages, and their interactions in asthma pathogenesis.
- Subjects
T cells; PATHOLOGY; ASTHMA; CROSSTALK; MACROPHAGES; VOCAL cord dysfunction
- Publication
Mediators of Inflammation, 2020, p1
- ISSN
0962-9351
- Publication type
Article
- DOI
10.1155/2020/7835284