We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Global test for high-dimensional mediation: Testing groups of potential mediators.
- Authors
Djordjilović, Vera; Page, Christian M.; Gran, Jon Michael; Nøst, Therese H.; Sandanger, Torkjel M.; Veierød, Marit B.; Thoresen, Magne
- Abstract
We address the problem of testing whether a possibly high-dimensional vector may act as a mediator between some exposure variable and the outcome of interest. We propose a global test for mediation, which combines a global test with the intersection-union principle. We discuss theoretical properties of our approach and conduct simulation studies that demonstrate that it performs equally well or better than its competitor. We also propose a multiple testing procedure, ScreenMin, that provides asymptotic control of either familywise error rate or false discovery rate when multiple groups of potential mediators are tested simultaneously. We apply our approach to data from a large Norwegian cohort study, where we look at the hypothesis that smoking increases the risk of lung cancer by modifying the level of DNA methylation.
- Subjects
FALSE discovery rate; MEDIATION; ERROR rates; DNA methylation; COMPUTER simulation; STATISTICS; RESEARCH; RESEARCH methodology; LUNG tumors; EVALUATION research; MEDICAL cooperation; COMPARATIVE studies; RESEARCH funding; STATISTICAL models; SMOKING; PROBABILITY theory; LONGITUDINAL method
- Publication
Statistics in Medicine, 2019, Vol 38, Issue 18, p3346
- ISSN
0277-6715
- Publication type
journal article
- DOI
10.1002/sim.8199