We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Total pelvic exenteration for rectal cancer: outcomes and prognostic factors.
- Authors
Domes, Trustin S.; Colquhoun, Patrick H. D.; Taylor, Brian; Izawa, Jonathan I.; House, Andrew A.; Luke, Patrick P. W.
- Abstract
Background: To perform complete resection of locally advanced and recurrent rectal carcinoma, total pelvic exenteration (TPE) may be attempted. We identified disease-related outcomes and prognostic factors. Methods: We conducted a single-centre review of patients who underwent TPE for rectal carcinoma over a 10-year period. Results: We included 28 patients in our study. After a median follow-up of 35 months, 53.6% of patients were alive with no evidence of disease. The 3-year actuarial disease-free and overall survival rates were 52.2% and 75.1%, respectively. On univariate analysis, recurrent disease, preoperative body mass index greater than 30 and lymphatic invasion were poor prognostic factors for disease-free survival, and only lymphatic invasion predicted overall survival. Additionally, multivariate analysis identified lymphatic invasion as an independent poor prognostic factor for disease-free survival in this patient population with locally advanced and recurrent rectal carcinoma. Conclusion: Despite the significant morbidity, TPE can provide long-term survival in patients with rectal carcinoma. Additionally, lymphatic invasion on final pathology was an independent prognostic factor for disease-free survival.
- Subjects
RECTAL cancer; SURGICAL excision; CANCER relapse; PELVIC exenteration; CANCER invasiveness; PROGNOSIS
- Publication
Canadian Journal of Surgery, 2011, Vol 54, Issue 6, p387
- ISSN
0008-428X
- Publication type
Article
- DOI
10.1503/cjs.014010