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- Title
Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes.
- Authors
Noso, Shinsuke; Ikegami, Hiroshi; Fujisawa, Tomomi; Kawabata, Yumiko; Asano, Katsuaki; Hiromine, Yoshihisa; Tsurumaru, Masako; Sugihara, Shigetaka; Lee, Inkyu; Kawasaki, Eiji; Awata, Takuya; Ogihara, Toshio
- Abstract
Association studies are a potentially powerful approach to identifying susceptibility variants for common multifactorial diseases such as type 1 diabetes, but the results are not always consistently reproducible. The IDDM5 locus has recently been narrowed to an approximately 200-kb interval on chromosome 6q25 by two independent groups. These studies demonstrated that alleles at markers in the mitogen-activating protein kinase 7 interacting protein 2 (MAP3K7IP2)/SUMO4 region were associated with susceptibility to type 1 diabetes. Subsequent studies, however, showed inconsistency in the association of the SUMO4 gene with type 1 diabetes. To clarify the contribution of the M55V polymorphism of the SUMO4 gene to type 1 diabetes susceptibility, 541 type 1 diabetic patients and 768 control subjects were studied in Asian populations. The M55V polymorphism was significantly associated with type 1 diabetes in Asian populations (summary odds ratio [OR] 1.46, P = 0.00083, Mantel-Haenszel test). Meta-analysis of published studies and the present data confirmed a highly significant association in Asian populations (summary OR 1.29, P = 7.0 x 10(-6)) but indicated heterogeneity in the genetic effect of the SUMO4/MAP3K7IP2 locus on type 1 diabetes among diverse ethnic groups. These data indicate that the MAP3K7IP2/SUMO4 locus in the IDDM5 interval is associated with type 1 diabetes in Asian populations.
- Subjects
JAPAN; KOREA; DIABETES; MEDICAL genetics; CHROMOSOMES; MITOGEN-activated protein kinases; MITOGENS; ASIANS; COMPARATIVE studies; DISEASE susceptibility; GENETIC polymorphisms; GENETICS; TYPE 1 diabetes; RESEARCH methodology; MEDICAL cooperation; PROTEINS; RESEARCH; WHITE people; EVALUATION research; GENOTYPES
- Publication
Diabetes, 2005, Vol 54, Issue 12, p3582
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diabetes.54.12.3582