We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
COVID-19 Molecular Pathophysiology: Acetylation of Repurposing Drugs.
- Authors
Lee, Jong Hoon; Kanwar, Badar; Khattak, Asif; Balentine, Jenny; Nguyen, Ngoc Huy; Kast, Richard E.; Lee, Chul Joong; Bourbeau, Jean; Altschuler, Eric L.; Sergi, Consolato M.; Nguyen, Tuan Ngoc Minh; Oh, Sangsuk; Sohn, Mun-Gi; Coleman, Michael
- Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces immune-mediated type 1 interferon (IFN-1) production, the pathophysiology of which involves sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) tetramerization and the cytosolic DNA sensor cyclic-GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling pathway. As a result, type I interferonopathies are exacerbated. Aspirin inhibits cGAS-mediated signaling through cGAS acetylation. Acetylation contributes to cGAS activity control and activates IFN-1 production and nuclear factor-κB (NF-κB) signaling via STING. Aspirin and dapsone inhibit the activation of both IFN-1 and NF-κB by targeting cGAS. We define these as anticatalytic mechanisms. It is necessary to alleviate the pathologic course and take the lag time of the odds of achieving viral clearance by day 7 to coordinate innate or adaptive immune cell reactions.
- Subjects
TYPE I interferons; SARS-CoV-2; DRUG repositioning; ACETYLATION
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 21, p13260
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms232113260