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- Title
Unraveling Mitochondrial Determinants of Tumor Response to Radiation Therapy.
- Authors
Zaffaroni, Mattia; Vincini, Maria Giulia; Corrao, Giulia; Marvaso, Giulia; Pepa, Matteo; Viglietto, Giuseppe; Amodio, Nicola; Jereczek-Fossa, Barbara Alicja
- Abstract
Radiotherapy represents a highly targeted and efficient treatment choice in many cancer types, both with curative and palliative intents. Nevertheless, radioresistance, consisting in the adaptive response of the tumor to radiation-induced damage, represents a major clinical problem. A growing body of the literature suggests that mechanisms related to mitochondrial changes and metabolic remodeling might play a major role in radioresistance development. In this work, the main contributors to the acquired cellular radioresistance and their relation with mitochondrial changes in terms of reactive oxygen species, hypoxia, and epigenetic alterations have been discussed. We focused on recent findings pointing to a major role of mitochondria in response to radiotherapy, along with their implication in the mechanisms underlying radioresistance and radiosensitivity, and briefly summarized some of the recently proposed mitochondria-targeting strategies to overcome the radioresistant phenotype in cancer.
- Subjects
RADIOTHERAPY; MITOCHONDRIA; RADIATION carcinogenesis; REACTIVE oxygen species; TREATMENT effectiveness; DOSE-response relationship (Radiation)
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 19, p11343
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms231911343