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- Title
Zika Virus: A New Therapeutic Candidate for Glioblastoma Treatment.
- Authors
Francipane, Maria Giovanna; Douradinha, Bruno; Chinnici, Cinzia Maria; Russelli, Giovanna; Conaldi, Pier Giulio; Iannolo, Gioacchin
- Abstract
Glioblastoma (GBM) is the most aggressive among the neurological tumors. At present, no chemotherapy or radiotherapy regimen is associated with a positive long-term outcome. In the majority of cases, the tumor recurs within 32–36 weeks of initial treatment. The recent discovery that Zika virus (ZIKV) has an oncolytic action against GBM has brought hope for the development of new therapeutic approaches. ZIKV is an arbovirus of the Flaviviridae family, and its infection during development has been associated with central nervous system (CNS) malformations, including microcephaly, through the targeting of neural stem/progenitor cells (NSCs/NPCs). This finding has led various groups to evaluate ZIKV's effects against glioblastoma stem cells (GSCs), supposedly responsible for GBM onset, progression, and therapy resistance. While preliminary data support ZIKV tropism toward GSCs, a more accurate study of ZIKV mechanisms of action is fundamental in order to launch ZIKV-based clinical trials for GBM patients.
- Subjects
ZIKA virus; THERAPEUTICS; GLIOBLASTOMA multiforme; VIRAL tropism; CENTRAL nervous system; PROGENITOR cells
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 20, p10996
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms222010996