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- Title
Human Polymerase δ-Interacting Protein 2 (PolDIP2) Inhibits the Formation of Human Tau Oligomers and Fibrils.
- Authors
Kasho, Kazutoshi; Krasauskas, Lukas; Smirnovas, Vytautas; Stojkovič, Gorazd; Morozova-Roche, Ludmilla A.; Wanrooij, Sjoerd
- Abstract
A central characteristic of Alzheimer's disease (AD) and other tauopathies is the accumulation of aggregated and misfolded Tau deposits in the brain. Tau-targeting therapies for AD have been unsuccessful in patients to date. Here we show that human polymerase δ-interacting protein 2 (PolDIP2) interacts with Tau. With a set of complementary methods, including thioflavin-T-based aggregation kinetic assays, Tau oligomer-specific dot-blot analysis, and single oligomer/fibril analysis by atomic force microscopy, we demonstrate that PolDIP2 inhibits Tau aggregation and amyloid fibril growth in vitro. The identification of PolDIP2 as a potential regulator of cellular Tau aggregation should be considered for future Tau-targeting therapeutics.
- Subjects
TAU proteins; ATOMIC force microscopy; OLIGOMERS; ALZHEIMER'S disease; PROTEINS
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 11, p5768
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22115768