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- Title
Molecular Research on Platelet Activity in Health and Disease 2.0.
- Authors
Catani, Maria Valeria; Savini, Isabella; Tullio, Valentina; Gasperi, Valeria
- Abstract
Hsia and collaborators [[1]] describe the ability of auraptene, the most abundant coumarin derivative from plants, in reducing platelet activity, via NF- B-dependent reduction in phospholipase C 2(PLC 2)-protein kinase C (PKC) activity. They also identify several factors regulating the platelet-activating potential of plasmin; among them, deserving of special mention is thrombospondin-1 that, depending on its concentration, can act as cofactor or inhibitor of plasmin-induced platelet activation [[4]]. As exposed by Dziedzic's study, SP-MS patients display increased formation of platelet aggregates, platelet-derived microparticles and platelet-leukocyte aggregates, as well as greater surface P-selectin expression, with respect to control subjects. Consequently, although CCNY/mice have fewer circulating platelets, nonetheless their platelets respond to thrombin and to a thromboxane A2 analog in a superimposable manner to platelet from wild-type mice.
- Subjects
MICROTUBULES; BLOOD platelets; ORGANELLE formation
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 9, p4968
- ISSN
1661-6596
- Publication type
Editorial
- DOI
10.3390/ijms22094968