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- Title
Extracellular Vesicles as Signaling Mediators and Disease Biomarkers across Biological Barriers.
- Authors
Simeone, Pasquale; Bologna, Giuseppina; Lanuti, Paola; Pierdomenico, Laura; Guagnano, Maria Teresa; Pieragostino, Damiana; Del Boccio, Piero; Vergara, Daniele; Marchisio, Marco; Miscia, Sebastiano; Mariani-Costantini, Renato
- Abstract
Extracellular vesicles act as shuttle vectors or signal transducers that can deliver specific biological information and have progressively emerged as key regulators of organized communities of cells within multicellular organisms in health and disease. Here, we survey the evolutionary origin, general characteristics, and biological significance of extracellular vesicles as mediators of intercellular signaling, discuss the various subtypes of extracellular vesicles thus far described and the principal methodological approaches to their study, and review the role of extracellular vesicles in tumorigenesis, immunity, non-synaptic neural communication, vascular-neural communication through the blood-brain barrier, renal pathophysiology, and embryo-fetal/maternal communication through the placenta.
- Subjects
BLOOD-brain barrier; BIOLOGICAL tags; EXOSOMES; EXTRACELLULAR vesicles; MULTICELLULAR organisms; PATHOLOGICAL physiology
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 7, p2514
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21072514