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- Title
Joint Effects of PON1 Polymorphisms and Vegetable Intake on Ischemic Stroke: A Family-Based Case Control Study.
- Authors
Juan Juan; Xia Jiang; Xun Tang; Yiqun Wu; Kexin Sun; Xiao Xiang; Yaohua Tian; Tao Wu; Qi Sun; Kraft, Peter; Yonghua Hu
- Abstract
Paraoxonase 1 gene (PON1) polymorphisms and dietary vegetable and fruit intake are both established determinants of ischemic stroke (IS). However, little is known about whether these factors jointly influence the risk of IS. We analyzed the main effects of PON1, as well as the interactions between PON1 and dietary vegetable or fruit intake with the risk of total IS and its subtypes in a family-based case-control study conducted among 2158 Chinese participants (1007 IS cases and 1151 IS-free controls) from 918 families. Conditional logistic regression models, with each family as a stratum, were used to examine the association between rs662 and IS. Gene-diet interactions were tested by including a cross-product term of dietary vegetable or fruit intake by rs662_G allele count in the models. Each copy of the PON1 rs662_G allele was associated with 28% higher risk of total IS (p = 0.008) and 32% higher risk of large artery atherosclerosis subtype (LAA) (p = 0.01). We observed an interaction between rs662 and vegetable intake for both total IS (p = 0.006) and LAA (p = 0.02) after adjustment for covariates. Individuals who carry the rs662_A allele may benefit to a greater extent from intake of vegetables and thus be more effectively protected from ischemic stroke, whereas carriers of the G allele may still remain at greater risk for ischemic stroke due to their genetic backgrounds even when they consume a high level of vegetables. More studies are needed to replicate our findings among other populations.
- Subjects
GENETIC polymorphisms; STROKE; VEGETABLES in human nutrition; FRUIT in human nutrition; PARAOXONASE
- Publication
International Journal of Molecular Sciences, 2017, Vol 18, Issue 12, p2652
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms18122652