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- Title
Osteoblast Role in Rheumatic Diseases.
- Authors
Corrado, Addolorata; Maruotti, Nicola; Cantatore, Francesco Paolo
- Abstract
Alterations in osteoblast growth, differentiation and activity play a role in the pathogenesis of several rheumatic diseases, such as rheumatoid arthritis, spondyloarthritides, osteoarthritis, and osteoporosis. In fact, in these rheumatic diseases, abnormal activity of Wnt signaling, receptor activator of nuclear factor-κB (RANK)-RANK ligand (RANKL)-osteoprotegerin (OPG) signaling, bone morphogenetic proteins (BMPs) pathway and other mechanisms have been described in osteoblasts. This review article is focused on current knowledge on the role of osteoblast dysregulation occurring in rheumatic diseases.
- Subjects
RHEUMATISM; RHEUMATISM treatment; OSTEOBLASTS; OSTEOPROTEGERIN; ARTHRITIS; PATIENTS
- Publication
International Journal of Molecular Sciences, 2017, Vol 18, Issue 6, p1272
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms18061272