We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Exploiting Epigenetic Alterations in Prostate Cancer.
- Authors
Baumgart, Simon J.; Haendler, Bernard
- Abstract
Prostate cancer affects an increasing number of men worldwide and is a leading cause of cancer-associated deaths. Beside genetic mutations, many epigenetic alterations including DNA and histone modifications have been identified in clinical prostate tumor samples. They have been linked to aberrant activity of enzymes and reader proteins involved in these epigenetic processes, leading to the search for dedicated inhibitory compounds. In the wake of encouraging anti-tumor efficacy results in preclinical models, epigenetic modulators addressing different targets are now being tested in prostate cancer patients. In addition, the assessment of microRNAs as stratification biomarkers, and early clinical trials evaluating suppressor microRNAs as potential prostate cancer treatment are being discussed.
- Subjects
PROSTATE cancer &; genetics; PROSTATE cancer treatment; BIOMARKERS; ANDROGEN receptors; EPIGENETICS; ANTINEOPLASTIC agents
- Publication
International Journal of Molecular Sciences, 2017, Vol 18, Issue 5, p1017
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms18051017