We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Evaluation of a Standardized Extract from Morus alba against α-Glucosidase Inhibitory Effect and Postprandial Antihyperglycemic in Patients with Impaired Glucose Tolerance: A Randomized Double-Blind Clinical Trial.
- Authors
Hwang, Seung Hwan; Li, Hong Mei; Lim, Soon Sung; Wang, Zhiqiang; Hong, Jae-Seung; Huang, Bo
- Abstract
To evaluate the antihyperglycemic effect of a standardized extract of the leaves of Morus alba (SEMA), the present study was designed to investigate the α-glucosidase inhibitory effect and acute single oral toxicity as well as evaluate blood glucose reduction in animals and in patients with impaired glucose tolerance in a randomized double-blind clinical trial. SEMA was found to inhibit α-glucosidase at a fourfold higher level than the positive control (acarbose), in a concentration-dependent manner. Moreover, blood glucose concentration was suppressed by SEMA in vivo. Clinical signs and weight changes were observed when conducting an evaluation of the acute toxicity of SEMA through a single-time administration, with clinical observation conducted more than once each day. After administration of the SEMA, observation was for 14 days; all of the animals did not die and did not show any abnormal symptoms. In addition, the inhibitory effects of rice coated with SEMA were evaluated in a group of impaired glucose tolerance patients on postprandial glucose and a group of normal persons, and results showed that SEMA had a clear inhibitory effect on postprandial hyperglycemia in both groups. Overall, SEMA showed excellent potential in the present study as a material for improving postprandial hyperglycemia.
- Subjects
FOLIAR diagnosis; HYPERGLYCEMIA prevention; ANIMAL experimentation; BLOOD sugar; BLOOD sugar monitoring; DOSE-effect relationship in pharmacology; HYPOGLYCEMIC agents; INGESTION; RICE; PLANT extracts; RANDOMIZED controlled trials; BLIND experiment; IN vivo studies; PHARMACODYNAMICS
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2016, Vol 2016, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2016/8983232