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- Title
Respiratory virus detection in the upper respiratory tract of asymptomatic, community-dwelling older people.
- Authors
Yasuda, Ikkoh; Suzuki, Motoi; Maeda, Haruka; Terada, Mayumi; Sando, Eiichiro; Ng, Chris Fook Sheng; Otomaru, Hirono; Yoshida, Lay-Myint; Morimoto, Konosuke
- Abstract
<bold>Background: </bold>The prevalence of virus positivity in the upper respiratory tract of asymptomatic community-dwelling older people remains elusive. Our objective was to investigate the prevalence of respiratory virus PCR positivity in asymptomatic community-dwelling older people using saliva samples and nasopharyngeal and oropharyngeal swabs.<bold>Methods: </bold>We analyzed 504 community-dwelling adults aged ≥ 65 years who were ambulatory and enrolled in a cross-sectional study conducted from February to December 2018 in Nagasaki city, Japan. Fourteen respiratory viruses were identified in saliva, nasopharyngeal and oropharyngeal samples using multiplex PCR assays.<bold>Results: </bold>The prevalences of PCR positivity for rhinovirus, influenza A, enterovirus and any respiratory virus were 12.9% (95% CI: 10.1-16.1%), 7.1% (95% CI: 5.1-9.8%), 6.9% (95% CI: 4.9-9.5%) and 25.2% (95% CI: 21.5-29.2%), respectively. Rhinovirus was detected in 21.5% of subjects, influenza A in 38.9% of subjects, enterovirus in 51.4% of subjects and any virus in 32.3% of subjects using only saliva sampling.<bold>Conclusions: </bold>The prevalences of several respiratory viruses were higher than the percentages reported previously in pharyngeal samples from younger adults. Saliva sampling is a potentially useful method for respiratory virus detection in asymptomatic populations.
- Subjects
JAPAN; OLDER people; VIRUSES; INFLUENZA epidemiology; CROSS-sectional method; RESPIRATORY infections; NASOPHARYNX; INDEPENDENT living; POLYMERASE chain reaction; RNA viruses; ENTEROVIRUS diseases
- Publication
BMC Infectious Diseases, 2022, Vol 22, Issue 1, p1
- ISSN
1471-2334
- Publication type
journal article
- DOI
10.1186/s12879-022-07355-w