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- Title
Synthesis and Antitumor Activity Evaluation of Some Novel-Fused and Spiro Heterocycles Derived from a 2(3 H)-Furanone Derivative.
- Authors
Abou ‐ Elmagd, Wael S. I.; Hashem, Ahmed I.
- Abstract
2(3 H)-furanone 1 was fused with methyl-4-aminobenzoate followed by to give the acid hydrazide derivative 3. Treatment of 3 with gave 4-amino-5-mercapto-3-substituted triazole derivative 5. The presence of mercapto and amino groups adjacent to each other in compound 5 made it valuable key precursor for the formation of fused and spiro heterocycles. Ring transformation of 5 into triazolothiadiazole and triazolothiadiazine derivatives is investigated. The antitumor and antimicrobial activities of the synthesized compounds were evaluated. Some of the tested compounds showed promising activities.
- Subjects
HETEROCYCLIC compound derivatives; FURANONES; ANTINEOPLASTIC agents; AMINOBENZOIC acid synthase; HYDRAZIDES
- Publication
Journal of Heterocyclic Chemistry, 2016, Vol 53, Issue 1, p202
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.2401