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- Title
Sox9 Is Upstream of MicroRNA-140 in Cartilage.
- Authors
Nakamura, Yukio; He, Xinjun; Kato, Hiroyuki; Wakitani, Shigeyuki; Kobayashi, Tatsuya; Watanabe, Sumiko; Iida, Atsumi; Tahara, Hideaki; Warman, Matthew; Watanapokasin, Ramida; Postlethwait, John
- Abstract
MicroRNA-140 (miR-140) is specifically expressed in developing cartilage tissues. We have previously reported that miR-140 plays an important role during palatal cartilage development by modulating platelet- derived growth factor receptor alpha ( pdgfra) in zebrafish. However, the regulatory mechanism of miR-140 in cartilage is still unknown. Using developing zebrafish, sox9a mutant ( sox9a−/−) and sox9b mutant ( sox9b−/−) zebrafish and SOX9 small interfering RNA in human chondrocytes, T/C-28 cells, we found that miR-140 is regulated by the cartilage master transcription regulator Sox9 in zebrafish and mammalian cells.
- Subjects
MICRORNA; CARTILAGE; ZEBRA danio; SMALL interfering RNA; IN situ hybridization
- Publication
Applied Biochemistry & Biotechnology, 2012, Vol 166, Issue 1, p64
- ISSN
0273-2289
- Publication type
Article
- DOI
10.1007/s12010-011-9404-y