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- Title
Enantioselective Lewis-Base-Catalyzed Asymmetric Hydrosilylation of Substituted Benzophenone N-Aryl Imines: Efficient Synthesis of Chiral (Diarylmethyl)amines.
- Authors
Hu, Xiao ‐ Yan; Zhang, Min ‐ Min; Shu, Chang; Zhang, Yong ‐ Hong; Liao, Li ‐ Hua; Yuan, Wei ‐ Cheng; Zhang, Xiao ‐ Mei
- Abstract
Lewis-base-catalyzed asymmetric hydrosilylation of substituted benzophenone N-aryl imines was investigated. Among various chiral Lewis-base catalysts, a catalyst derived from L-Serine was found to be the most favorable one which promote the reaction to afford a series of (diarylmethyl)amines with high yields (up to 97 %) in moderate to good enantioselectivities (up to 97 % ee). The absolute configuration of the product was determined by the X-ray crystallographic analysis.
- Subjects
ENANTIOSELECTIVE catalysis; HYDROSILYLATION; BENZOPHENONES; IMINE synthesis; CHEMICAL reactions
- Publication
Advanced Synthesis & Catalysis, 2014, Vol 356, Issue 17, p3539
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201400643