We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
First Total Synthesis of Prionoid E, A Bioactive Rearranged Secoabietane Diterpene Quinone from Salvia prionitis.
- Authors
Deng, Fei; Xu, Jun; Zhao, Min; Liu, Hong-Ying; Ye, Yang; Zhang, Jin-Sheng
- Abstract
The article describes the first total synthesis of prionoid E, a secoabietane diterpene quinone isolated from Salvia prionitis, through Wacker oxidation and aldol condensation, the primary steps in the synthetic sequence. Prionoid E was prepared in 15 steps in 3.7% yield beginning from anisole and methylsuccinic anhydride on one hand, and from 2-hydroxy-2-methylpropanoic acid on the other hand. The application of this method to synthesis prionoid E and its analogs for evaluation of their biological activity is reportedly ongoing.
- Subjects
DITERPENES; SALVIA; OXIDATION; ALDOL condensation; ANHYDRIDES
- Publication
Helvetica Chimica Acta, 2011, Vol 94, Issue 7, p1326
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201000435