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- Title
A New Route to the Synthesis of 2-Amino-6-(methoxycarbonyl)amino-4-(tetrahydropyridyl)pyrimidine 1-Oxide.
- Authors
Muller, Jean-Claude; Ramuz, Henri; Wagner, Hans-Peter
- Abstract
A new approach to 2-amino-6-(methoxycarbonyl)amino-4-(1,2,3,6-tetrahydro-1-pyridyl)pyrimidine 1-oxide ( 3) is described. Methyl [1-ethoxy-2-(ethoxycarbonyl)-ethylidene]carbamate ( 5) reacted with guanidine to the pyrimidinecarbamate 6, which was successively transformed into methyl 2-amino-6-( p-tolyslulfonyl)oxy-4-pyrimidinecarbamate ( 8). Oxidation of 8 led to the corresponding pyrimidine N-oxide 9, a useful starting material to 3.
- Publication
Helvetica Chimica Acta, 1983, Vol 66, Issue 3, p809
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19830660313