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- Title
Mycophenolate mofetil-induced pseudotumor cerebri in a boy with autoimmune lymphoproliferative disease.
- Authors
Patiroglu, Turkan; Ozcan, Alper; Karakukcu, Musa; Ozdemir, Mehmet Akif; Poyrazoglu, Gamze; Canpolat, Mehmet; Unal, Ekrem
- Abstract
Introduction: Pseudotumor cerebri (PTC) is a syndrome characterized with increased intracranial pressure, normal cerebrospinal fluid content (CSF), and a normal brain on imaging studies. In this case report, PTC has been linked to mycophenolate mofetil (MMF) that has been used for autoimmune lymphoproliferative syndrome (ALPS). Case report: A 5-year-old boy, who was using MMF for 4 months because of the ALPS, suffered from occipital headache and vomiting with no other symptom. The initial physical examination was normal expect bilateral papilledema. The patient underwent a lumbar puncture which showed elevated opening pressure (590 mmHO) but no laboratory abnormalities of the CSF. A diagnosis of PTC was established. MMF was stopped, and the child was started on an acetazolamide treatment for 2 weeks. His symptoms and complaints recovered after this treatment. Discussion: According to our knowledge, we report the first case of MMF-induced PTC in a boy with ALPS. This case illustrates that despite the rarity of MMF-induced PTC, the physicians should be aware of this possibility. Furthermore, in the setting of new-onset headaches or visual changes, early ophthalmologic examination for papilledema is recommended for early diagnosis.
- Subjects
MYCOPHENOLIC acid; INTRACRANIAL hypertension; LYMPHOPROLIFERATIVE disorders; BRAIN diseases; CEREBROSPINAL fluid
- Publication
Child's Nervous System, 2011, Vol 27, Issue 5, p853
- ISSN
0256-7040
- Publication type
Report
- DOI
10.1007/s00381-011-1402-4