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- Title
Single-cell DNA sequencing reveals order of mutational acquisition in TRAF7/AKT1 and TRAF7/KLF4 mutant meningiomas.
- Authors
Dogan, Helin; Blume, Christina; Patel, Areeba; Jungwirth, Gerhard; Sogerer, Lisa; Ratliff, Miriam; Ketter, Ralf; Herold-Mende, Christel; Jones, David T. W.; Wick, Wolfgang; Vollmuth, Philipp; Zweckberger, Klaus; Reuss, David; von Deimling, Andreas; Sahm, Felix
- Abstract
Most meningiomas carry mutations in the tumor suppressor neurofibromatosis gene 2 (NF2) on chromosome 22q, while I NF2 i -wildtype meningiomas account for about a third of all meningiomas [[4], [7]]. Interestingly, 1/7 samples showed one clone carrying only a heterozygous I KLF4 i mutation and another with the I KLF4 i mutation along with the I TRAF7 i mutation, both in addition to a wildtype clone.
- Subjects
DNA sequencing
- Publication
Acta Neuropathologica, 2022, Vol 144, Issue 4, p799
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/s00401-022-02485-6