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- Title
Proton Pump Inhibitor Improves Breath Marker in Moderate Asthma with Gastroesophageal Reflux Disease.
- Authors
Shimizu, Yasuo; Dobashi, Kunio; Jian Jun Zhao; Kawata, Tadayoshi; Ono, Akihiro; Yanagitani, Noriko; Kaira, Kyoichi; Utsugi, Mitsuyoshi; Hisada, Takeshi; Ishizuka, Tamotsu; Mori, Masatomo
- Abstract
Background: Gastroesophageal reflux disease (GERD) influences the symptoms of asthma with acid and oxidative stress. Objectives: The purpose of this study was to determine the usefulness of measurement of the acid stress marker pH and the oxidative stress marker 8-isoprostane by exhaled breath condensate in proton pump inhibitor (PPI) therapy effect on moderate asthma patients with GERD. Methods: The pH and the concentration of 8-isoprostane were measured in the exhaled breath condensate of patients with moderate asthma (n = 36) and healthy subjects (n = 26). Two months of PPI therapy (lansoprazole at 30 mg/day) were done in the asthma patients with (n = 13) or without (n = 13) GERD according to a questionnaire for the diagnosis of reflux disease, and exhaled markers were measured. Results: The pH was lower (7.3 ± 0.3) and the 8-isoprostane level was higher (27.7 ± 2.3) in the asthma patients than in the healthy control subjects (pH 7.5 ± 0.2 and 8-isoprostane 6.6 ± 1.2). Two months of PPI therapy improved the pH (from 7.2 ± 0.1 to 7.3 ± 0.1) and the 8-isoprostane concentration (from 32.7 ± 3.4 to 19.2 ± 3.4) in the asthma patients with GERD, along with improvement of GERD symptoms. However, these markers did not change in the asthma patients without GERD. Conclusions: Measurement of the pH and 8-isoprostane level of exhaled breath condensate may be useful to evaluate the influence of GERD on asthma, as well as to determine the timing of intermittent PPI therapy. Copyright © 2007 S. Karger AG, Basel
- Subjects
ASTHMA; PROTON pump inhibitors; GASTROESOPHAGEAL reflux; OXIDATIVE stress; HYDROGEN-ion concentration
- Publication
Respiration, 2007, Vol 74, Issue 5, p558
- ISSN
0025-7931
- Publication type
Article
- DOI
10.1159/000101437