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- Title
5-FU induced cardiotoxicity: case series and review of the literature.
- Authors
Yuan, Cai; Parekh, Hiral; Allegra, Carmen; George, Thomas J.; Starr, Jason S.
- Abstract
Background: 5-Fluorouracil (5-FU) is an antimetabolite chemotherapy used for a variety of solid tumors. It has the potential to cause a wide spectrum of cardiotoxicity, ranging from asymptomatic electrocardiographic changes to cardiomyopathy and subsequent cardiac failure. Main body of the abstract: We present two descriptive cases of new-onset severe cardiomyopathy induced by 5-FU followed by a review of the literature. Conclusion: Our case series emphasizes the importance of early recognition of this rare complication and prompt cessation of 5-FU, as cardiac dysfunction in this context is potentially reversible.
- Publication
Cardio-Oncology, 2019, Vol 5, Issue 1, pN.PAG
- ISSN
2057-3804
- Publication type
Article
- DOI
10.1186/s40959-019-0048-3