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- Title
Clinical Practice of Adjuvant Chemotherapy in Patients with Early-Stage Epithelial Ovarian Cancer.
- Authors
Frielink, Lindy M.J.; Pijlman, Brenda M.; Ezendam, Nicole P.M.; Pijnenborg, Johanna M.a.
- Abstract
Background: Adjuvant platinum-based chemotherapy improves survival in women with early-stage epithelial ovarian cancer (EOC). Yet, there is a wide variety in clinical practice. Methods: All patients diagnosed with FIGO I and IIa EOC (2006-2010) in the south of the Netherlands were analyzed. The percentage of patients that received adjuvant chemotherapy was determined as well as the comprehensiveness of staging and outcome. Results: Forty percent (54/135) of the patients with early-stage EOC received adjuvant chemotherapy. Treatment with adjuvant chemotherapy was associated with FIGO stage, clear-cell histology and nonoptimal staging. Optimal staging was achieved in 50%, and nonoptimal staging was associated with advanced age, comorbidity and treatment in a non-referral hospital. Overall, there was no difference in outcome between patients with and without adjuvant chemotherapy. Yet, in grade 3 tumors, adjuvant chemotherapy seems beneficial. Conclusions: Selective treatment of patients with early-stage EOC might reduce adjuvant chemotherapy without compromising outcome.
- Subjects
NETHERLANDS; CANCER chemotherapy; ADJUVANT treatment of cancer; OVARIAN epithelial cancer; PLATINUM; DISEASES in women; CANCER treatment; THERAPEUTICS
- Publication
Chemotherapy (0009-3157), 2016, Vol 61, Issue 6, p287
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000445024