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- Title
Emerging Resistant Gram-Negative Aerobic Bacilli in Hospital-Acquired Infections.
- Authors
Kunz, Anjali N.; Brook, Itzhak
- Abstract
The increasing emergence of serious multidrug-resistant (MDR) Gram-negative infections has led to a new health-care crisis. These infections predominately include MDR Pseudomonas aeruginosa, extended-spectrum beta-lactamase-producing Enterobacteriaceae and MDR Acinetobacter baumannii. These organisms are present in a variety of clinical settings, but there is a distinct paucity of antibiotics to effectively treat these infections. The increasing use of broad-spectrum antibiotics and lack of good stewardship have contributed to the increase in these MDR organisms. This review focuses on the main MDR Gram-negative infections contributing to the current crisis in health care, their mechanisms of resistance and various treatment options for empiric therapy. Copyright © 2010 S. Karger AG, Basel
- Subjects
GRAM-negative bacteria; DRUG resistance in microorganisms; MEDICAL care; PSEUDOMONAS aeruginosa; ACINETOBACTER infections; ANTIBIOTICS; ENTEROBACTERIACEAE; MULTIDRUG resistance
- Publication
Chemotherapy (0009-3157), 2010, Vol 56, Issue 6, p492
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000321018