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- Title
The contribution of bone to whole-organism physiology.
- Authors
Karsenty, Gérard; Ferron, Mathieu
- Abstract
The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiology can broaden the functions of a given organ, reveal connections of this organ with others such as the brain, pancreas and gut, and shed new light on the pathogenesis of degenerative diseases affecting multiple organs.
- Subjects
PHYSIOLOGICAL research; GENE expression; LABORATORY mice; SKELETON; ENERGY metabolism regulation; DEGENERATION (Pathology); ANATOMY
- Publication
Nature, 2012, Vol 481, Issue 7381, p314
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature10763