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- Title
Virology: Bornavirus enters the genome.
- Authors
Feschotte, Cédric
- Abstract
The article reports on the study made by M. Horie and colleagues on non-retroviral viruses, also known as borna disease viruses (BDV), in mammalian evolution. The said virus was a unique kind of virus that infects birds and mammals' neurons by establishing persistent infection in its brain. When they searched 234 available eukaryotic genomes to a virus similar to that of BDV, they unearthed a plethora of endogenous Borna-like N (EBLN) elements in several mammals which they believed to occur in different times and multiple mammalian lineages. Moreover, they concluded that BDV was a source of mutation in infected individuals and associated with certain psychiatric disorders like schizophrenia and mood disorders.
- Subjects
BORNA disease virus; BRAIN disease research; MAMMAL diseases; MENTAL illness; GENOMES; RETROVIRUS diseases; SCHIZOPHRENIA; AFFECTIVE disorders; HORIE, M.
- Publication
Nature, 2010, Vol 463, Issue 7277, p39
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/463039a