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- Title
Role of DRD2 and ALDH2 genes in bipolar II disorder with and without comorbid anxiety disorder.
- Authors
Wang, Y.-S.; Lee, S.-Y.; Chen, S.-L.; Chang, Y.-H.; Wang, T.-Y.; Lin, S.-H.; Wang, C.-L.; Huang, S.-Y.; Lee, I.H.; Chen, P.S.; Yang, Y.K.; Lu, R.-B.
- Abstract
Abstract: The presence of comorbid anxiety disorders (AD) and bipolar II disorders (BP-II) compounds disability complicates treatment, worsens prognosis, and has been understudied. The genes involved in metabolizing dopamine and encoding dopamine receptors, such as aldehyde dehydrogenase 2 (ALDH2) and dopamine D2 receptor (DRD2) genes, may be important to the pathogenesis of BP-II comorbid with AD. We aimed to clarify ALDH2 and DRD2 genes for predisposition to BP-II comorbid with and without AD. The sample consisted of 335 subjects BP-II without AD, 127 subjects BP-II with AD and 348 healthy subjects as normal control. The genotypes of the ALDH2 and DRD2 Taq-IA polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. Logistic regression analysis showed a statistically significant association between DRD2 Taq-I A1/A2 genotype and BP-II with AD (OR=2.231, P =0.021). Moreover, a significant interaction of the DRD2 Taq-I A1/A1 and the ALDH2*1*1 genotypes in BP-II without AD was revealed (OR=5.623, P =0.001) compared with normal control. Our findings support the hypothesis that a unique genetic distinction between BP-II with and without AD, and suggest a novel association between DRD2 Taq-I A1/A2 genotype and BP-II with AD. Our study also provides further evidence that the ALDH2 and DRD2 genes interact in BP-II, particularly BP-II without AD.
- Subjects
COMORBIDITY; BIPOLAR disorder; ANXIETY disorders; DOPAMINE receptors; ALDEHYDE dehydrogenase; GENETIC polymorphisms
- Publication
European Psychiatry, 2014, Vol 29, Issue 3, p142
- ISSN
0924-9338
- Publication type
Article
- DOI
10.1016/j.eurpsy.2013.05.001