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- Title
P02-35 - Effect of adjunctive aripiprazole in achieving various levels of response and on domains of functioning in MDD: A pooled analysis
- Authors
Gismondi, R.; Cain, Z.; Fabian, T.; Rollin, L.; Forbes, R.; Berman, R.; Baker, R.; Casey, D.; Laubmeier, K.; Marler, S.V.; Loze, J.-Y.
- Abstract
Introduction: Major Depressive Disorder (MDD) patients experience different levels of response and functionality impairments. Objectives/aims: Evaluate levels of response for adjunctive aripiprazole therapy (AA) and effects of AA on patient functioning. Methods: Data were pooled from three similar, randomized, double-blind, placebo-controlled trials with aripiprazole in MDD. Quartile response categories were defined by reduction (%) in MADRS >6 weeks of treatment: Minimal response (≤25%), Partial response (>25% to < 50%), Moderate response (≥50% to < 75%), and Robust response (≥75%). Proportions of placebo (AP) vs. AA patients achieving a response were compared (Cochran-Mantel-Haenszel test) for each category. Functionality was assessed using mean changes in Sheehan Disability Scale (SDS) scores. Changes in scores were compared (ANCOVA) between AA and AP. Results: AA had more patients (%) compared with AP achieving partial (23.9% vs. 17.9%, p=0.017), moderate (23.1% vs. 15.0%, p< 0.001), and robust responses (14.3% vs. 7.4%, p< 0.001). AA had less (%) achieving minimal response compared with AP (38.7% vs. 59.6%, p< 0.001). Mean changes are below. Conclusions: Most inadequate responders who continued on AP were minimal responders (60%). 60% of aripiprazole patients rapidly achieved partial, moderate or robust response status. AA significantly improved social and family life domains of functioning.
- Subjects
MENTAL depression; THERAPEUTICS; ANTIDEPRESSANTS; ANTIPSYCHOTIC agents; PLACEBOS; DEPRESSED persons; MENTAL illness
- Publication
European Psychiatry, 2011, Vol 26, p630
- ISSN
0924-9338
- Publication type
Abstract
- DOI
10.1016/S0924-9338(11)72336-7