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- Title
HP08 DOES NEO-ADJUVANT CHEMOTHERAPY AFFECT THE ACCURACY OF FDG-PET FOR PRE-OPERATIVE PLANNING IN HEPATIC COLORECTAL METASTASES?
- Authors
Adie, S.; Yip, C.; Chu, F.; Morris, D. L.
- Abstract
Purpose Pre-op scanning for hepatic colorectal metastases surgery remains a challenge, especially in the age of neo-adjuvant chemotherapy, which has marked biochemical and physical effects on the liver. FDG-PET has clear applications for detecting extrahepatic disease. We investigated FDG-PET as a pre-op planning tool for detecting lesions in patients with and without neo-adjuvant chemotherapy. Methodology All patients who had resection of hepatic colorectal metastases between Jan 2004 and June 2006 were included. Patients were divided into those who received neo-adjuvant chemotherapy and those who did not. The number of malignant hepatic lesions found on each scan was compared with those found on histopathology, intra-operative examination and/or intra-operative ultrasound. Accurate scans (scan lesions = true lesions), over-estimations (scan lesions > true lesions) and under-estimations (scan lesions < true lesions) were recorded. Results 21 patients had pre-op FDG-PET scans with neo-adjuvant chemotherapy and 53 without. Accurate tests on a per-patient basis were 6 (29%) for the chemotherapy group vs. 28 (53%) for the non-chemotherapy group, p = 0.06. Notably, there were 11 (52%) under-estimations in the chemotherapy group vs. 18 (34%) in the non-chemotherapy group. There were 4 (19%) over-estimations in the chemotherapy group vs. 7 (13%) in the non-chemotherapy group. Conclusion Pre-op assessment with FDG-PET is not useful for hepatic colorectal metastases, particularly when neo-adjuvant chemotherapy is used. FDG-PET is still useful however, for the assessment of extra-hepatic disease.
- Subjects
ABSTRACTS; PREOPERATIVE care; COLON cancer; METASTASIS; COLON surgery; DRUG therapy
- Publication
ANZ Journal of Surgery, 2007, Vol 77, p41
- ISSN
1445-1433
- Publication type
Article
- DOI
10.1111/j.1445-2197.2007.04122_8.x