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- Title
The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection.
- Authors
Chang, Aileen Y.; Tritsch, Sarah; Reid, St. Patrick; Martins, Karen; Encinales, Liliana; Pacheco, Nelly; Amdur, Richard L.; Porras-Ramirez, Alexandra; Rico-Mendoza, Alejandro; Li, Guangzhao; Peng, Jin; Firestein, Gary S.; Simon, Gary L.; Bethony, Jeff M.
- Abstract
The cytokine profile during acute chikungunya infection that predicts future chronic arthritis has not yet been investigated. We conducted a nested case-control study comparing serum cytokine concentrations during acute chikungunya infection in cases (n = 121) that reported the presence of chronic joint pain versus age- and gender-matched controls (n = 121) who reported recovery at 20 months post infection. We observed that a robust cytokine response during acute infection was correlated with a decreased incidence of chronic joint pain and that low TNFα, IL-13, IL-2, and IL-4 during acute infection was predictive of chronic joint pain. These data suggest that a robust cytokine response is necessary for viral clearance and cytokines that are related to immune tolerance during acute infection may be protective for chronic arthritis pathogenesis.
- Subjects
CYTOKINES; CHIKUNGUNYA virus; ARTHRITIS; JOINT pain; IMMUNE response
- Publication
Diseases, 2018, Vol 6, Issue 4, p95
- ISSN
2079-9721
- Publication type
Article
- DOI
10.3390/diseases6040095