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- Title
Disease Severity and Effective Parasite Multiplication Rate in Falciparum Malaria.
- Authors
Kingston, Hugh W; Ghose, Aniruddha; Plewes, Katherine; Ishioka, Haruhiko; Leopold, Stije J; Maude, Richard J; Paul, Sanjib; Intharabut, Benjamas; Silamut, Kamorat; Woodrow, Charles
- Abstract
Patients presenting with severe falciparum malaria in a Bangladeshi tertiary hospital had higher total parasite burden, estimated by parasitemia and plasma PfHRP2, than uncomplicated malaria patients despite shorter fever duration. This suggests that higher parasite multiplication rates (PMR) contribute to causing the higher biomass found in severe disease. Compared with patients without a history of previous malaria, patients with previous malaria carried a lower parasite biomass with similar fever duration at presentation, suggesting that host immunity reduces the PMR.
- Subjects
BIOTIC communities; FEVER; MALARIA; PARASITES; SEVERITY of illness index
- Publication
Open Forum Infectious Diseases, 2017, Vol 4, Issue 4, pN.PAG
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofx169