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- Title
Relationship between serum vitamin D levels and inflammatory markers in acute stroke patients.
- Authors
Wang, Qiongzhang; Zhu, Zhuoying; Liu, Yuntao; Tu, Xinjie; He, Jincai
- Abstract
Abstract: Introduction: Low serum vitamin D levels are associated with the development of poststroke depression (PSD). Inflammatory markers play an important role in pathophysiology of PSD. The relationship between vitamin D levels and inflammatory markers has been discussed in nonstroke individuals. The purposes of this study were to explore the relationship between vitamin D levels and inflammatory markers in acute stroke patients and examine the effect of vitamin D and inflammatory markers on PSD. Methods: A total of 152 acute stroke patients were recruited. Serum levels of 25‐hydroxyvitamin D and inflammatory markers were measured by standardized laboratory methods. Depression symptoms were assessed with the 17‐item Hamilton Depression Scale (HAMD‐17). Patients with the HAMD‐17 scores ≥7 were identified to have depression symptoms. Results: Serum vitamin D levels were negatively correlated with serum levels of interleukin‐6 and high‐sensitivity C‐reactive protein (hsCRP) (<italic>r</italic> = −.244, <italic>p</italic> = .002; <italic>r</italic> = −.231, <italic>p</italic> = .004). Multiple regression analysis showed that interleukin‐6 and hsCRP levels were associated with vitamin D levels (<italic>B</italic> = −0.355, <italic>p</italic> = .003; <italic>B</italic> = −2.085, <italic>p</italic> = .006), whereas age, height, weight, leukocyte count, neutrophil ratio, and lymphocyte rate could be omitted without changing the results. In multivariate analyses, the serum levels of vitamin D and interleukin‐6 were associated with the development of PSD after adjusted possible variables (OR = 0.976, 95% CI: 0.958–0.994, <italic>p</italic> = .009; OR = 1.029, 95% CI: 1.003–1.055, <italic>p</italic> = .027). Conclusions: Serum vitamin D levels are inversely associated with the levels of interleukin‐6 and hsCRP, suggesting a potential anti‐inflammatory role for vitamin D in stroke individuals.
- Subjects
VITAMIN D content of food; BLOOD serum analysis; STROKE; BIOMARKERS; INFLAMMATION; MENTAL depression
- Publication
Brain & Behavior, 2018, Vol 8, Issue 2, p1
- ISSN
2162-3279
- Publication type
Article
- DOI
10.1002/brb3.885