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- Title
Frequency of sensitization to the individual fragrances of fragrance mix I and II according to the factors included in the MOAHLFA index.
- Authors
Sánchez‐Pujol, María J.; Docampo‐Simón, Alexandre; Mercader, Pedro; González‐Pérez, Ricardo; Hervella‐Garcés, Marcos; Sanz‐Sánchez, Tatiana; Córdoba, Susana; Sánchez‐Pérez, Javier; Heras‐Mendaza, Felipe; Giménez‐Arnau, Ana M.; Gatica‐Ortega, María E.; Pastor‐Nieto, María A.; Zaragoza, Violeta; Carrascosa, José M.; García‐Bravo, Begoña; Ruiz‐González, Inmaculada; Borrego, Leopoldo; Sánchez‐Pedreño, Paloma; Frutos, Javier O.; Armario‐Hita, José C.
- Abstract
Background: Fragrances constitute the second most frequent cause of allergic contact dermatitis in Spain. Objectives: To determine the rate of sensitization to the individual fragrances of fragrance mix (FM) I and FM II for each of the demographic and clinical factors included in the MOAHLFA (male, occupational dermatitis, atopic dermatitis, hand dermatitis, leg dermatitis, facial dermatitis, age) index. Methods: We conducted a 5‐year retrospective study in 23 Spanish centres. We identified the patients who had undergone patch testing with a specific fragrance series after reacting positively to fragrance markers in a baseline series. We obtained the MOAHLFA index items in this population, then calculated for each demographic and clinical factor the frequencies of sensitization to the individual fragrances of FM I and FM II. Results: A specific fragrance series was patch tested in 1013 patients. The most frequent allergens in men, women, children, and retired people were Evernia prunastri (16%), geraniol (16.6%), isoeugenol (17.9%), and geraniol (22.4%), respectively. Citral (20.5%) and hydroxyisohexyl 3‐cyclohexene carboxaldehyde (HICC) (14.5%) were the most common allergens in occupational eczemas and were also associated with a large proportion of hand and facial dermatitis. Conclusions: Frequency of sensitization to the individual fragrances of FM I and FM II varies with age, sex, affected body region, and history of occupational or atopic dermatitis.
- Subjects
SPAIN; ECZEMA; PROTHROMBIN; ATOPIC dermatitis; CONTACT dermatitis; RETIREES; SKIN inflammation
- Publication
Contact Dermatitis (01051873), 2021, Vol 84, Issue 6, p395
- ISSN
0105-1873
- Publication type
Article
- DOI
10.1111/cod.13801