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- Title
Factors predicting the blood glucose lowering effect of a 30-day very low calorie diet in obese Type 2 diabetic patients.
- Authors
Jazet, I.M.; Pijl, H.; Frölich, M.; Schoemaker, R.C.; Meinders, A.E.
- Abstract
To identify factors which predict the blood glucose lowering effect of monotherapy with a 30-day very low calorie diet (VLCD) in obese Type 2 diabetic patients. A responder was a priori defined as a patient with a fasting plasma glucose (FPG) level< 10 mmol/l on day 30.In 17 obese patients (BMI 37.6 ± 5.6 (mean± SD) kg/m2) with Type 2 diabetes, all blood glucose lowering medication (including insulin) was discontinued on day−1 followed by a 30-day VLCD. On day 2 and 30 of the VLCD an intravenous glucose tolerance test (IVGTT) was performed.Of the 14 patients who completed the 30-day VLCD, eight qualified as responder. Responders and non-responders could be distinguished by day 2. Responders had a shorter duration of Type 2 diabetes and higher fasting serum insulin, C-peptide and HOMA-β-values. In addition, responders displayed a more prominent second-phase insulin response following i.v. glucose loading and higher k-values. In a stepwise discriminant analysis, the change in FPG from day 0 to day 2 (responders+0.64 ± 2.3, non-responders+4.15 ± 3.3 mmol/l,P = 0.035) in combination with the area under the curve of insulin (AUC) above baseline during an IVGTT on day 2 (responders 571 ± 236, non-responders 88 ± 65 mU*50 min,P < 0.001), distinguished responders completely from non-responders.Preservation of the capacity ofβ-cells to secrete insulin predicts a favourable metabolic response to a VLCD in obese Type 2 diabetic patients.Diabet. Med. (2004)
- Subjects
BLOOD plasma; GLUCOSE; SUGAR in the body; LOW-calorie diet; PEOPLE with diabetes; OVERWEIGHT persons
- Publication
Diabetic Medicine, 2005, Vol 22, Issue 1, p52
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/j.1464-5491.2004.01357.x