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- Title
Role of ABO Blood Group in SARS-CoV-2 Infection in Households.
- Authors
Janda, Ales; Engel, Corinna; Remppis, Jonathan; Enkel, Sigrid; Peter, Andreas; Hörber, Sebastian; Ganzenmueller, Tina; Schober, Sarah; Weinstock, Christof; Jacobsen, Eva-Maria; Fabricius, Dorit; Zernickel, Maria; Stamminger, Thomas; Dietz, Andrea; Groß, Hans-Jürgen; Bode, Sebastian F. N.; Haddad, Anneke D. M.; Elling, Roland; Stich, Maximilian; Tönshoff, Burkhard
- Abstract
An association between certain ABO/Rh blood groups and susceptibility to SARS-CoV-2 infection has been proposed for adults, although this remains controversial. In children and adolescents, the relationship is unclear due to a lack of robust data. Here, we investigated the association of ABO/Rh blood groups and SARS-CoV-2 in a multi-center study comprising 163 households with 281 children and 355 adults and at least one SARS-CoV-2 seropositive individual as determined by three independent assays as a proxy for previous infection. In line with previous findings, we found a higher frequency of blood group A (+ 6%) and a lower frequency of blood group O (−6%) among the SARS-CoV-2 seropositive adults compared to the seronegative ones. This trend was not seen in children. In contrast, SARS-CoV-2 seropositive children had a significantly lower frequency of Rh-positive blood groups. ABO compatibility did not seem to play a role in SARS-CoV-2 transmission within the families. A correction for family clusters was performed and estimated fixed effects of the blood group on the risk of SARS-CoV-2 seropositivity and symptomatic infection were determined. Although we found a different distribution of blood groups in seropositive individuals compared to the reference population, the risk of SARS-CoV-2 seropositivity or symptomatic infection was not increased in children or in adults with blood group A or AB versus O or B. Increasing age was the only parameter positively correlating with the risk of SARS-CoV-2 infection. In conclusion, specific ABO/Rh blood groups and ABO compatibility appear not to predispose for SARS-CoV-2 susceptibility in children.
- Subjects
BLOOD groups; ABO blood group system; SARS-CoV-2; HOUSEHOLDS
- Publication
Frontiers in Microbiology, 2022, Vol 13, p1
- ISSN
1664-302X
- Publication type
Article
- DOI
10.3389/fmicb.2022.857965