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- Title
AGEING, OESTROGEN, PLATELETS AND THROMBOTIC RISK.
- Authors
Miller, Virginia M; Jayachandran, Muthuvel; Owen, Whyte G
- Abstract
1. Adverse thrombotic cardiovascular events increase in women coincident with the onset of menopause. 2. Age past menopause may be an important variable in defining the benefit/risk of hormone treatments. 3. Few studies have examined hormonal status as a variable of aging using a polygenomic approach of both humoral and cellular components of the coagulation system. 4. Longitudinal studies of a global set of platelet functions that define procoagulant activity (i.e. adhesion, aggregation, secretion and thrombin production) in individuals with documented hormonal status are needed to better understand how hormonal changes associated with aging impact thrombotic risk.
- Subjects
THROMBOSIS risk factors; BLOOD coagulation; CARDIOVASCULAR diseases; HORMONE therapy for menopause; BLOOD platelets; OLDER people
- Publication
Clinical & Experimental Pharmacology & Physiology, 2007, Vol 34, Issue 8, p814
- ISSN
0305-1870
- Publication type
Article
- DOI
10.1111/j.1440-1681.2007.04685.x