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- Title
Identification of myo‐inositol hexakisphosphate (IP6) as a β‐secretase 1 (BACE1) inhibitory molecule in rice grain extract and digest.
- Authors
Abe, Takako K.; Taniguchi, Masayuki
- Abstract
Alzheimer's disease (AD) is widely considered to be caused by amyloid‐β peptide (Aβ) accumulation in the brain. Aβ is excised from amyloid‐β precursor protein through sequential cleavage by β‐secretase 1 (BACE1) and γ‐secretase. Thus, BACE1 inhibition could prevent Aβ accumulation. Here, we identified myo‐inositol hexakisphosphate (IP6) as a BACE1 inhibitory molecule in rice grain extract and digest. The rice digest and IP6 significantly inhibited Aβ production in neuroblastoma cells without cytotoxicity. These results suggested that rice components, including IP6, may be promising starting materials for the development of potent and safe drugs and/or food to prevent AD.
- Subjects
ALZHEIMER'S disease; AMYLOID beta-protein; BRAIN diseases; COMPOSITION of rice; DRUG development
- Publication
FEBS Open Bio, 2014, Vol 4, Issue 1, p162
- ISSN
2211-5463
- Publication type
Article
- DOI
10.1016/j.fob.2014.01.008