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- Title
Route and Type of Formulation Administered Influences the Absorption and Disposition of Vitamin B<sub>12</sub> Levels in Serum.
- Authors
Vitetta, Luis; Zhou, Joyce; Manuel, Rachel; Dal Forno, Serena; Hall, Sean; Rutolo, David
- Abstract
The administration of biological compounds that optimize health benefits is an ever-evolving therapeutic goal. Pharmaceutical and other adjunctive biological compounds have been administered via many different routes in order to produce a systemic pharmacological effect. The article summarizes the findings from an Australian comparative study in adults administered vitamin B12 through different oral delivery platforms. A total of 16 subjects (9males, 7 females) voluntarily partook in a comparative clinical study of five different vitamin B12 formulations across a six-month period, completing 474 person-hours of cumulative contribution, that was equivalent to an n = 60 participation. A nanoparticle delivered vitamin B12 through a NanoCelle platformwas observed to be significantly (p < 0.05) better absorbed than all other dose equivalent platforms (i.e., tablets, emulsions, or liposomes) frombaseline to 1, 3, and 6 h of the study period. The nanoparticle platform delivered vitamin B12 demonstrated an enhanced and significant absorption profile as exemplified by rapid systemic detection (i.e., 1 h frombaseline) when administered to the oro-buccal mucosa with no reports of any adverse events of toxicity. The nanoparticle formulation of methylcobalamin (1000 µg/dose in 0.3 mL volume) showed bioequivalence only with a chewable-dissolvable tablet that administered a five times higher dose of methylcobalamin (5000 µg) per tablet. This study has demonstrated that an active metabolite embedded in a functional biomaterial (NanoCelle) may constitute a drug delivery method that can better access the circulatory system.
- Subjects
VITAMIN B12; THERAPEUTIC equivalency in drugs
- Publication
Journal of Functional Biomaterials, 2018, Vol 9, Issue 1, p12
- ISSN
2079-4983
- Publication type
Article
- DOI
10.3390/jfb9010012