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- Title
Sustained Delivery of Chondroitinase ABC from Hydrogel System.
- Authors
Rossi, Filippo; Veglianese, Pietro; Santoro, Marco; Papa, Simonetta; Rogora, Cristina; Dell'Oro, Valentina; Forloni, Gianluigi; Masi, Maurizio; Perale, Giuseppe
- Abstract
In the injured spinal cord, chondroitin sulfate proteoglycans (CSPGs) are the principal responsible of axon growth inhibition and they contribute to regenerative failure, promoting glial scar formation. Chondroitinase ABC (chABC) is known for being able to digest proteoglycans, thus degrading glial scar and favoring axonal regrowth. However, its classic administration is invasive, infection-prone and clinically problematic. An agarose-carbomer (AC1) hydrogel, already used in SCI repair strategies, was here investigated as a delivery system capable of an effective chABC administration: the material ability to include chABC within its pores and the possibility to be injected into the target tissue were firstly proved. Subsequently, release kinetic and the maintenance of enzymatic activity were positively assessed: AC1 hydrogel was thus confirmed to be a feasible tool for chABC delivery and a promising device for spinal cord injury topic repair strategies.
- Subjects
SPINAL cord injuries; CHONDROITIN sulfate proteoglycan; CHONDROITINASE; HYDROGELS; AGAROSE; PROTEOGLYCANS
- Publication
Journal of Functional Biomaterials, 2012, Vol 3, Issue 1, p199
- ISSN
2079-4983
- Publication type
Article
- DOI
10.3390/jfb3010199